The two warring families have a number of similarities to the Lancasters and Yorks. Their names are similar. The Lancasters were known for their wealth. The Yorks were from the north. Both families believed they had claim to the the throne of Richard II, who was deposed.
Their dispute, known as the War of Roses, lasted from 1455-1487.
Looking for a GOT spoiler? The battle was won by the Lancasters, putting Henry VII on the throne. But with a stroke of diplomacy he ended the feud by marrying a York.
Number 4: Henry Tudor and Daenerys Targaryen